The article from Biomedicine & Pharmacotherapy focuses on novel vaccine candidates for Chlamydia trachomatis, delivered via intradermal administration. This approach leverages bacterial protein bodies (PBs) as a vehicle to induce immune responses, which were shown to be effective in preclinical trials.
The research highlights two main vaccine candidates based on PBs containing antigens derived from C. trachomatis. The vaccines induced strong cellular and humoral immune responses, which included significant levels of neutralizing antibodies in mouse models. Particularly, one of the candidates, PB-CTH522-SP, showed a reduction in bacterial load following genital challenge, marking a significant step toward the development of a viable vaccine for chlamydia.
The findings support PB-based platforms as promising tools for enhancing vaccine efficacy, providing an effective and scalable alternative to traditional vaccine methods. These platforms enable sustained antigen presentation and can generate both CD4+ and CD8+ T-cell responses, crucial for fighting intracellular pathogens like C. trachomatis. The study emphasizes the importance of continuing this research for broader application and exploring long-term efficacy(
If you would like further details, the full article is accessible through open access at Biomedicine & Pharmacotherapy (Volume 180, 2024).
Sexually transmitted infections top Alaska’s annual disease list, reflecting high rates
By
Yereth Rosen, Alaska Beacon
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November 18, 2024
A flier posted on a bulletin board at the University of Alaska Anchorage on April 20 gives information about tests for sexually transmitted infections. Alaska has some of the nation’s highest rates of chlamydia and gonorrhea. (Photo by Yereth Rosen/Alaska Beacon)
Alaska’s most commonly reported infectious diseases, aside from respiratory illnesses such as influenza, are from sexually transmitted infections, according to the state’s most recent annual report.
There were 5,118 cases of chlamydia in Alaska in 2023, the largest number among sexually transmitted diseases in the annual infectious disease report issued by the Alaska Department of Health.
The infectious disease annual reports…